“It is already possible to live to be well over 120 years (…) In my own laboratory at UCLA Medical Center, we have extended the maximum life span of fish by 300 percent.” Maximum Life Span”, NY: W. W. Norton, 1983 by Roy L. Walford, M.D.
- 1 Purpose of Master Class on Cancer-free Optimal Longevity
- 2 The Originality of this Training
- 3 Lesson 1: Introduction
- 4 Lesson 2: The Basics of Biogerontology
- 5 Lesson 3. The Biology of Aging
- 6 Lesson 4: The Hallmarks of Accelerated Aging & Cancer
- 7 The Biology and Hallmarks of Cancer
- 7.1 Key take-away Lesson: We should befriend commensal microbes instead of systematically and blindly killing them with antibiotics and the like. The greater diverse & more peaceful & resilient the Microbiota, the more these commensal microbes will disarm the pathogenic microbes and assist human cells to optimizing healthy Lifespan.
- 8 Tentative Conclusion
- 9 To Read the synopsis of Lessons 5 and 6, click here.
- 10 Video Excerpt on a 2016 Optimal Longevity Medicine Lecture from Pr. Joubert
Purpose of Master Class on Cancer-free Optimal Longevity
The Raison d’Etre of this Master Class is to train attendees so that they can restore the 120 years Gift of Life that has been bestowed upon them. With few if any chronic diseases. subsidiarily, we encourage attendees to become Optimal Longevity & Holistic Cancer coaches for themselves and others.
The Originality of this Training
This Master class addresses cancer & other chronic diseases from the longevity and bio-terrain angle with the best available Science and healing practices we know of. By addressing the tumor (s) microenvironment as well as the person’s bioterrain holistically and with Optimal Longevity medicine, the body will more often than not resolve the cancer as well as many of the other degenerative challenges the patient may be suffering from. Furthermore, as a bonus for activating the longevity pathways, the Master Class attendee enriches his or her bioterrain with what is needed to live a long healthy lifespan of 120 years old.
The following evidence-strong 32 Lessons are based on the latest research in cancer-free longevity science. Each Lesson lasts around two hours. Clinical Pearls, Holistic Tips and a Q & A session follow each Lesson. Mid-term and at the end of the training, two certification exams are offered, both of which can be retaken if needed. We do all we can to get attendees competent, certified and ready to do their part is spreading holistic savoir-faire and healing wisdom.
We will prove all of the Institute’s claims with a preponderance of the hard evidence during the online and in situ power point presentations.
Each Lesson will be preceded with a longevity enhancement type of Meditation exercise
Lesson 1: Introduction
The Magic of Meditation: From Genomic Expression to Joie de Vivre (JDV) Consciousness Activation
“I regard consciousness as fundamental. I regard matter as derivative from consciousness” Max Planck (leading expert in quantic physics, Nobel laureate)
Researchers at the University of California were the first to show that meditators have significantly higher telomerase activity than non-meditators. (Source) Furthermore, the regular practice of specific types of Meditations we teach all Workshop attendees will simultaneously signal longevity genes to activate telomerase enzyme gene and many other biological processes to sharpen both intuition and focus. As a bonus, intellectual assimilation of the content of this Certification program will be enhanced. We will therefore begin and end each 2 hours training Lesson with short guided Meditation practices.
Introduction to Cancer-free Holistic Rejuvenation and “Anti-aging” Medicine
“The field of ageing research has been completely transformed in the past decade. . . . When single genes are changed, animals that should be old stay young. In humans, these mutants would be analogous to a ninety year old who looks and feels forty-five. On this basis we begin to think of ageing as a disease that can be cured, or at least postponed. . . . The field of ageing is beginning to explode, because so many are so excited about the prospect of searching for – and finding – the causes of ageing, and maybe even the fountain of youth itself”. (Guarente and Kenyon, Nature, 2000)
For millennia, the aging process has been considered to be uncontrollable, even when the average lifespan did not surpass 40 years, which was just a little over 100 years ago. That changed with Professor Elizabeth Blackburn’s discovery of the telomerase gene. (Source) Furthermore, in the early nineties, research on C. elegans, (a tiny nematode worm) confirmed that a single gene mutation extended its life, and that another mutation blocked that extension. (Source)
The idea that age could be tweaked by twiddling a few control genetic switches ignited a research and investment boom. As more geroscientists and biogerontologists got better motivated to attempt to break and hack the Longevity Code, new findings started to reveal key biological clocks that epigenically switched on and off longevity genes. (See Exhibit C)
In this perspective, various clinical interventions did increase the worm’s lifespan by a factor of ten and those of lab mice by a factor of two. (Source) Thereafter, telomeres of skin cells were tweaked to lengthen the new unprecedented levels, thanks to a new Lab procedure fine-tuned by Stanford university School of Medicine scientists. These cells were able to divide up to 40 more times more than untreated cells, which means that human somatic cells have been empirically shown to surpass the Hayflick limit and potentially extend their lifespan 40 times more than before. “Skin cells with telomeres lengthened by the procedure were able to divide up to 40 more times than untreated cells”. (Source)
This means that we now have some limited evidence that we may have in us the regenerative potential to live 40 times more than the Hayflick limit. The Havflick limit is in between 50 to 70 cellular divisions, before the cell either dies or transitions into a senescent cell. Seventy divisions are roughly 120 years. 40 times 120 = 4800 years.
The scientific consensus that human lifespan potential was a little after 100 years old thus transformed. The perception of the Aging process went from a few decades of endless struggling to survive to a Darwinian reproduction of the human species (Cf Time cover from 1958: “Growing Old Usefully”), followed by a social issue (Time, 1970: “Growing Old in America: The Unwanted Generation”) to this “je ne sais quoi” phenomenon (1996: “Forever Young”) that could defer death to 142 years for starts (Cf 2015: Time “This Baby Could Live to Be 142 Years Old”).
However, because in Life, there are many howevers, the excitement was not long lasting. Successfully tweaking genes in a Petri dish does not necessarily translate into in vivo genetic expressions of supercentenarian lifespan. It was soon discovered that the telomerase enzyme gene was not the central longevity engine anti-aging experts had hoped for. The Longevity Code cook-book is far more complex for mammals and even more so for humans than for a C. Elegans worm, fly, mouse, naked mole or even the bat (who has an exceptionally long lifespan).
Hence, the Institute’s director, Pr. Joubert, prefers to focus on the known fundamentals that work to at least 122 years of age while simultaneously exploring the best of bio-tech longevity engineering stratagems, many of which are still in the early phases of clinical trials and concomitant marketing schemes.
As we will see, there are many dozens of ongoing drugs and supplements that are already being used in today’s anti-aging and baby-boomer communities, from telomerase activators and senescent cell removal, (senolytics) to autophagy inducers, caloric restriction mimickers, blood donor plasma transfer, nano-robots, mTOR drugs like rapamycin, gene editing, NAD enhancers, stem cell cyro-preservation, sirtuin-activating molecules, insulin-modulating drugs like metformin and more.
Some of these products are still under investigation in different clinical trials. Not only it can take many years for many of these anti-aging human trials to be completed, but thereafter, many of these anti-aging products will be too expensive for the general public and many of these products are not immune from deleterious side effects.
As a consequence, risks may outweigh benefits, especially for people who are relatively healthy and are just seeking to add 30 or 40 extra healthy years to their lifespan.
Thus, waiting a few years before some of these bio-tech longevity hacks may be accessible and proven safe and effective is not cellularly or financially responsible, if only because today we have the knowledge that key holistic tools can significantly help to rejuvenate, repair and restore most metabolically impaired tissues to way over 100 years. Furthermore, Holistic and Happiness medicine can also meaningfully help to offset and significantly delay Evolution’s programmed aging process. In effect, by addressing cancer cells holistically with the ACR Institute’s discoveries and techniques, we can also clear senescent, ectopic endometrial and other degenerative cells and debris that hinder healthy supercentenarian lifespans, the over-all impact of which allows both the immune system and stem cells to work better.
Lesson 2: The Basics of Biogerontology
“ …aging can be modulated by genetic pathways and biochemical processes which are evolutionarily conserved” (Lopez‐Otin et al., 2013)
After a brief introduction, the workshopees will be introduced to the evidence that corroborates the reality of healthy long human lifespans (in between 110 and 122 years of age). In this context, we will examine supercentenarian individuals like Jeanne Calment (who reached 122 years) and many others, the longevity valleys and blue zones as well as the scientific debates regarding maximum human lifespans. These analyses will help us to identify the key longevity factors that characterize some of these geographical areas where healthy centenarians are abundant. Thereafter, we will examine the aging and longevity biomarkers as well as the major hallmarks or biochemical pathways of aging.
Biogerontology: principles and key Findings
Distinction between Accelerated and Delayed Aging
The ACR and O.L. Institutes’ central Premise on Aging and Longevity
Nobel Professors of Physiology whose recent findings have meaningfully enhanced the value of Rejuvenation Medicine
Biomarkers (Aging and Longevity)
The Epigenetic Clock
Case studies of a few Humans and Animals who have significantly outlived their peers
Top: The French Mediterranean dancer, Madame Jeanne Calment, a Piscean born on February 21, 1875, is still the Optimal Longevity Champion, notwithstanding some evidentiary controversies. Having reached 122.5 years, according to her claims, she “allowed” herself to die. In other words, she could have continued to live. Her age was confirmed via birth certificate and the Guiness Record scientist-investigators, in conjunction with university experts, confirmed this fact as well as many other facts that proved beyond any reasonable doubt that human beings were capable of reaching 122 years of Life without major chronic diseases and without any drugs or supplements. In this picture, she was 120.
In this Case Study, we will examine the Life and thoughts of the Mediterranean supercentenarian Champion Jeanne Calment whose longevity record has never been broken. (Source) We will also look at her lifestyle, her diet and her medical records that span from 111 years to 118. Thereafter, we will make an evidence-based determination as to what kept her going for over 122 years. A few other super centenarians as well as animals will be compared to this all time longevity record breaker. And yes, she drank red wine with her Med-diet meals, (with, on occasion A2 quality cheese & wild fish), had a great sense of humor and enjoyed lots of dark chocolate, up to one kilo a week (2.2. pounds). (Source) But according to Jeanne herself, French scientists and her doctor, her healthy lifespan secret was something else.
Lesson 3. The Biology of Aging
Understanding the Mechanisms that Spur Accelerated & Delayed Aging
“Medicine is not only a science; it is also an art. It does not consist of compounding pills and plasters; it deals with the very processes of life, which must be understood before they may be guided.” Paracelsus
To be motivated to adopt a Holistic Restorative and Rejuvenation Lifestyle, it is first necessary to understand the mechanisms that govern normal aging in relation to accelerated aging and slow holistic “delayed” aging. When we see that sustainable Lifestyle and holistic savoir-faire impact all of the major hallmarks of aging, including gene expression, it is then easier to pay attention to what is important in Life, provided one desires a healthy supercentenarian existence. But one must genuinely and vividly desire to achieve this Life potential. The supercentenarian life is not for the faint of heart. To achieve this high vibrational level of Life, resistance against toxicity and activation of holistic techniques, including in the fields of relaxation, detox, exercises, meditation, up-beat attitude, hormesis, quality nutrition, sleep and vibrant water intake, among other elements, are more important than the genetic or zip codes.
What is Biological Aging & Senescence ?
Different Theories of Biological Aging
Cancer cells & Supercentenarians: Common threads
Top: A young infant girl who suffers from Proregia syndrome. She is only around 2 years old, but appears much more. Also known as Hutchinson-Gilford syndrome, this disease is genetic. It is characterized by accelerated aging that is accompanied with the age-related diseases. The mean age at death of these patients is 12.5 years. These children die “old” before 15 or 20, at which point they look like 80 years old.
Case study A: Ultra rapid metabolic accelerating-aging
Top: A 16 years old little girl who stopped growing at 11 months.
Case Study B: Ultra-slow Growth: Children who do not Age, genetically “frozen” in Time
Roundworms Experimentations confirm: aging and lifespan is regulated in part through the insulin/IGF-1 and mTOR pathways.
Top: the transparent nematodeC. elegans.This roundworm is one of the most studied for neurodegeneration and longevity. Scientists have been able to significantly extend its lifespans by tweaking its genes.
The IGF-1 & mTOR pathways
In Search for a Working Hypothesis of the Key mechanism(s) of Aging
The Major Molecular Mechanisms that best Explain the Aging Process
What are the genetic variants or determinants that account for extreme longevity in humans ? Do these variants prevail over Lifestyle and the environment ?
“Centenarians are the best example of extreme human longevity, and they represent a selected population in which the appearance of major age-related diseases, such as cancer, and cardiovascular diseases among others, has been consistently delayed or escaped. The study of the long-lived individual genetic profile has the purpose to possibly identify the genes and the allelic variations influencing extended life expectancy, hence considering them as biomarkers of age-related diseases onset and development. The present study shows no significant differences between allelic variations of ABO blood groups among a group of centenarians from Western Sicily”. (Source)
Longevity scientists have been researching “protective longevity genes” for a long time. Some of these “life extension” genes function via cellular defense compensatory mechanisms, in particular with regard to oxidative stress, autophagy and inflammation. In this field, we will look at three of the more important families of genes that modulate age-related pathways. These are the SIRTUINS, APOEs and FOXOs (FOXO1 and FOXO3) (Cf. Willcox et al., 2006 and Soerensen et al., 2010, 2015 and Brooks‐Wilson, 2013). The variant FOXO3A for example, is found in many German centenarians as well as in a few other ethnic groups around the world, (Source). On the other hand, FOXO4 has a role in maintaining the harmful state of cellular senescence by sabotaging that specific mechanism that has been shown to selectively push senescent cells into self destruction. So not all FOXO variants have been created equal. On the other hand, the sirtuin genes modulate only anti-aging pathways, but also helps with chronic diseases. (Source) And wine’s resveratrol is a sirtuin 1 activator. While APOE4 is problematic, its variant (allele) APOE2 is anti-aging. (Source)
In this session, we will briefly assess what is the relevance of longevity genes in relation to stochastic, environmental and epigenetic factors upon which humans have control. Later on in the master class, we will give a list of foods and supplements that can help to activate these and other longevity genes whose ribosomes produce proteins that have beneficial effects on multiple longevity pathways. (See ultra).
Top: Rosemary, one of the Mediterranean plants that is abundant in both the Mediterranean longevity valleys and in centenarians’ guts
Lesson 4: The Hallmarks of Accelerated Aging & Cancer
“The idea is to die young as late as possible.” (Ashley Montagu).
Accelerated Aging is characterized by a rapid loss of physiological integrity, paving the way to impaired function, increased vulnerability, un-necessary suffering, chronic diseases and death. This deterioration is the primary risk factor for major human pathologies including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. In the last couple of decades, longevity science has experienced unprecedented research breakthroughs, particularly with the discovery that the rate of aging is controlled by genetic pathways and biochemical processes conserved in evolution. In Holistic Medicine, we show that sustainable Lifestyle, Holistic Savoir-faire and non-invasive health interventions can significantly control this accelerated aging process so that humans can achieve their 120 years healthy lifespan potential. The Hallmarks below represent biological processes and common denominators of aging in different organisms, in particular with mammals. A major challenge is to dissect the interconnectedness between the below-mentioned hallmarks and their contribution to aging, with the final goal of identifying holistic formulas and Lifestyle codes that can extend healthy human Lifespan to beyond 120 years.
1. Genomic instability.
2. Mitochondrial DNA Break-down & Dysfunction
3. Telomere Shortening and Attrition. Telomerase Depletion
4. Epigenetic Alterations
5. Loss of Proteostasis
6. Deregulated Nutrient-sensing
7. Cellular Senescence & the proliferation of Senescent cells
8. Stem Cell Exhaustion
9. Altered Intercellular Communication.
Summary on the First Nine Hallmarks
10-14. Complementary Hallmarks identified by the ACR & OL Institutes
Analysis: Longevity Mechanisms in supercentenarian & long-lived animals
The Biology and Hallmarks of Cancer
Just like the complexities of the Biology of Aging, the complexities of the Biology of cancer can be reduced to a few underlying biochemical processes or “hallmarks”. Because both Aging and Cancer Hallmarks share common pathways, fixing accelerating aging will favorably impact on cancer resolution (control and reversal). This approach is the ACR Institute’s originality.
1. Cancer cells stimulate their own growth (self-sufficiency in growth signals)
2. Cancer cells resist inhibitory signals that might otherwise stop their growth (insensitivity to anti-growth signals)
3. Cancer cells resist their programmed cell death (evading apoptosis)
4. Cancer cells multiply indefinitely (limitless replicative potential)
5. Cancer cells stimulate the growth of blood vessels to supply nutrients to tumors (sustained angiogenesis)
6. Cancer cells invade local tissue and spread to distant sites (tissue invasion and metastasis).
7. Cancer cells have abnormal metabolic pathways & a dysfunctional mitochondria
8. Cancer cells evade the immune system & bath in its inflammation cascades
9. Cancer cells are spured by mutations and genome instability
Summary of the First 9 Cancer Hallmarks.
10-14. Complementary Cancer Hallmarks identified by the ACR & OL Institutes
Analysis: Cancer avoidance mechanisms in supercentenarian humans & long-lived animals
Top: The naked mole rat who also broke the world record for longevity in its category. This fleshy rat is one of the ACR and OL Institute’s Heros as the NM Rat has demonstrated successful Longevity pathways that are relevant to the OL Institute’s Optimal Longevity Model.
Negligible senescence in the longest living rodents, the naked mole-rats & their DNA repair system
Gompertz Aging law and Biological “Immortality”
Tentative Concluding Remarks on Senescence, Aging mechanisms and Cancer Hallmarks
As we see in the hallmarks sections, biological aging and carcinogenesis are a multi-factorial phenomenon, consisting of the loss of homeostasis at multiple scales of biological complexity, from the molecular (e.g., DNA and proteins) to the organelle, cell, tissue, organ and metabolic/system level. Genetic and, more importantly, environmental factors determine both the aging and metastatic process. Research in lab model organisms has demonstrated that single gene mutations can greatly impact life expectancy. For example, genes in the insulin and insulin-like growth factor 1, AMPK &TOR pathways significantly impact lifespan and cancer biology. Gene variations like in the FOXO 3 gene have also been associated in humans with supercentenarian and cancer-free status. As we will see, environmental interventions such as dietary restriction, changes in nutrient sensing, stress, changes in temperature, holistic lifestyle, superfoods and more modulate both healthy lifespans and cancer suppression.
The Master Class’ Starting Point and Guiding Hypothesis on a unified theory of aging: This Model will help to guide us with respect to identifying the major mechanisms that determine healthy cancer-free supercentenarian Lifespans.
For now, the ACR Institute’s working hypothesis derives from what we have advanced so far, in particular that the organismal process of aging, cancer and life itself appear to be strongly influenced if not governed by ancestral bacteria, including, but not limited to gut microbiota and cellular mitochondria. Mitochondria genes cross talk with the eukariotic cell’s own nuclear genes for the synergistic benefit of both entities (the eukariotic cell and the mitochondria), thanks to which Life and it’s maintenance were able to fine-tune from over one billion years ago to today. After many millions of years, this process evolved in millions of different Life forms, including human life. To understand how the cancer-free Longevity optimization process works, it is therefore important to realize that we are spiritual beings experiencing a microbe-bacteria-driving human Life.
One piece of evidence that supports this claim that the evolutionary origin of Human Life lies in the mitochondria can be found in single-celled protozoans. In the ciliates (e.g. paramecium), telomerase is not expressed in mitosis (when the cell copies itself), (Source) but only when it conjugates (recombining genes with other individuals) with another. (Source) Thus a cell that self replicates without mixing its genes with another is designed to quickly die of cell senescence. But for cells that self replicate by exchanging genes with a partner, here, teolmerase gets expressed. And this gene, called TERT is deeply connected to the mitochondria and human longevity.
Because most of the other important aging pathways we have examined are also under the strong influence of the mitochondria, in particular senescent cells, the P53 and stem cells, we therefore for now hypothesize that one of the central keys to optimal cancer-free longevity lies within both the mitochondria’s genome and its oxidative phosphorylation & ATP-AMPK system as well as the mitochondria’s gut brethren, within the microbiota and the nDNA-mtDNA circuit or axis and the Epigenome. Recent French discoveries on the microbiota’s role with respect to cancer reversals corroborate this piece of allegation. Likewise with recent discoveries on the microbiota’s role in extended longevity to over 100 years.
Key take-away Lesson: We should befriend commensal microbes instead of systematically and blindly killing them with antibiotics and the like. The greater diverse & more peaceful & resilient the Microbiota, the more these commensal microbes will disarm the pathogenic microbes and assist human cells to optimizing healthy Lifespan.
Dwelling at the interface between organisms and the environment, commensal microbes participate in many key biological processes, including but not limited to nutrient absorption, synthesis of essential vitamins, drug processing, pathogenicity, organ development, intestinal impermeability, circadian rhythms, and immune system maturation and modulation, blood sugar stability, protein translation, carbon metabolism, adhesion, amino acid and vitamin synthesis and much more. (Source) Among all organs, the human gut lumen harbours the largest amount and diversity of commensal microbes. Its composition and function have been associated with the modulation of the insulin signalling pathway and with the overall metabolic state of the host.(Source) As we will see during the development of this power-point Master Course, age-related frailty, accelerated aging and chronic disease conditions, including but not limited to cancer, are necessarily associated with the loss of specificity and diversity with regard to core microbiota group. (Source)
In the last hundreds of millions of years of co-evolution between human and commensal microbes, including those in organic raw A-2 cheese and yogurt and wine, we humans have become who we are today, with a healthy lifespan potential of around 120 years. Most supercentenarian who reach or get close to this 120 years limit don’t usually die from cancer, even as their stem cells get depleted and cellular mutations abound.
The totality of the evidence clearly shows that metabolic and genetic cross-talk between microbes and the multi-cellular human host ensures balanced homeostasis and finely regulated physiological processes, including but not limited to blood sugar stability, inflammation control, neuropeptide regulation and immune function. During accelerated aging, the complex interaction between host and its associated microbial communities undergoes important changes, which can result in dramatic phenotypic consequences for the host, including dysbiosis, infections, overall functional decline, complex chronic disease cascades and accelerated aging. As we will see, healthy immune systems and holistic medicine are key.
Telomere shortening and the other hallmarks we will examine are still relevant pathways. But with recent findings and breakthroughs in the world of the tiny microbes, we are for now putting the Telomere length (TL) factor on a back-burner. The Happiness Medicine and Optimal Longevity Institutes have elaborated a Theory on Aging on all of this, but the HM Institute’s website has crashed with a broken coding and the Optimal Longevity Institute has been incapacitated with artificial microbes (malware). So until these problems get fixed, the above link may not work.
We are now ready to examine how holistic medicine, innovative Science and millennia-based Holistic Tradition, including in Chinese and French medicine, can contribute to down-regulate the aging mechanisms and optimize healthy cancer-free lifespans to around 120 years. But first, we need to identify conventional medicine’s research limitations (weaknesses) and delve into methodology, science and the law.
To Read the synopsis of Lessons 5 and 6, click here.
Video Excerpt on a 2016 Optimal Longevity Medicine Lecture from Pr. Joubert
Top: Ted Talk on how Evolution has protected large animals from Cancer
“The stability of the internal environment (the milieu intérieur) is the condition for the free and independent life”. Professeur Claude Bernard (Dr Claude Bernard is one of the recognized fathers of modern medicine)
For the O.L Master Class’ Closing Remarks (from the Institute’s Book), click here. Reserved for the Registered Viewers
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