Closing Remarks (from the ACR Institute’s book)

My people are destroyed from lack of knowledge” (Hosea 4:6)

Aging is defined as a progressive decline in intrinsic physiological function, leading to an increase in degenerative diseases as well as an enhancement in age-specific mortality rates. Evolutionarily, aging also progressively hinders reproduction, though there are exceptions in Nature, including with the tortoise  whose eggs increase as she withstands the passage of time.

Some of the major theories of aging that this Master Class examines include telomere shortening theory, epigenetic and genetic regulation theory, stem cell theory, mitochondrial dysfunction, metabolic and immune deregulation, proteostasis loss and, among others, the gut microbiota regulating theory. Some of these aging hallmarks can be favorably fixed. Fixing the mechanisms of accelerated aging also benefits the resolution of many chronic diseases, including cancer. This is the ACR Institute’s preferred approach.

However, not all scientists  agree on all of the causes that explain the hallmarks of aging we identified, and in particular, the hierarchy of causation (which causes are the most important). From a close examination of the totality of factors, it appears that the central cause of accelerated aging and its degenerative diseases comes from this constant onslaught of low and not so low bombardment of polluting and toxic chemicals, fake & processed “food” and chronic stress the American government’s law-makers still refuse to properly regulate.

Promoting a holistic culture based on sustainability, holistic medicine, clean energy, a genuine prevention-based public health policy and a restructuring of the socio-economic landscape would  reduce both chronic diseases and accelerated aging, to the point where the lifespan norm (ie life expectancy) would be at least 90 years and beyond, like in the “blue zone” most blue zone experts forget, the Principality of French-cultured Monaco. (Source)

Since life began on Earth roughly 3.5 billion years ago, five major mass extinctions and several minor ones as well, have led to large and sudden drops in biodiversity and genetic variation(Source) During this course of evolutionary unfoldment, the human beings of today have lost around 80 key genes, including but not limited to the bio-synthesis of Vitamin C and other key functions this Master Class attempts to partially restore so that its coachees will be equipped with the knowledge to reach  120 years and beyond.

The Phanerozoic eon (the last 540 million years) marked a rapid growth in biodiversity via the Cambrian explosion, a period during which the majority of multicellular phyla first appeared. The next 400 million years included repeated, massive biodiversity losses classified as mass extinction events. In the Carboniferous, rainforest collapse led to a great loss of plant and animal life. The Permian–Triassic extinction event, 251 million years ago, was the worst; vertebrate recovery took 30 million years. The most recent, the Cretaceous–Paleogene extinction event, (Named the Holocene or Anthropocene extinction) occurred 65 million years ago and has often attracted more attention than others because it resulted in the extinction of the dinosaurs, today’s birds of which are one of the few flying creatures we still can enjoy. And since the emergence of humans, an ongoing biodiversity reduction and an accompanying loss of genetic diversity had grown almost exponentially.

In this historic perspective, the last 40 years has recorded the destruction of over half of all of wild Life.

The number of wild animals on Earth has halved in the past 40 years, according to a new analysis. Creatures across land, rivers and the seas are being decimated as humans kill them for food in unsustainable numbers, while polluting or destroying their habitats, the research by scientists at WWF and the Zoological Society of London found”. (Source)

Likewise with the destruction of our own bio-diverse microbiota, those little critters (archaea, fungi, viruses, bacteria and myriad parasites) whose millions of prokaryotic genes continuously cross-talk with our own eukaryotic genes, who were on Earth way before humans, who were instrumental for the key mechanisms of this thing called Life many billions of years ago and who continue to guide us to healthy longevity or an inflammatory & painful death.

Without holistic savoir-faire, microbiota science and a robust gut, optimal longevity, like the Planet’s survival, will remain too difficult to achieve.

But with the diffusion of Master Classes such as this one, healthy longevity can soon become a respected and even actionable fundamental right for all

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